RIMADYL® CHEWABLES (carprofen) Chewable Tablets

Description

Canine non-steroidal anti-inflammatory drug (NSAID) in oral dosage form
Selectively inhibits cyclooxygenase (COX)-2, which generates prostaglandins involved in inflammation. (In vitro, clinical relevance has not been shown). Once-daily dosage provides anti-inflammatory and analgesic effects for 24 hours.

Approved Uses

RIMADYL® CHEWABLES are approved for: Pain and inflammation associated with osteoarthritis in dogs. Control of postoperative pain associated with soft-tissue and orthopedic surgeries in dogs.

Key Features

First and most widely used veterinary NSAID approved in the U.S. for canine use. Chewable tablets are scored and available in three strengths for convenient dosing. Well tolerated in canine safety studies.

Packaging

RIMADYL Chewable Tablets are scored and contain 25 mg, 75 mg or 100 mg of carprofen per caplet or tablet. Each Chewable Tablet size is packaged in bottles containing 7, 14, 30, 60 or 180 tablets.

Dosage and Administration

The recommended dosage for oral administration to dogs is 2 mg/lb (4.4 mg/kg) of body weight daily. Total daily dose may be administered as 2 mg/lb of body weight once daily or divided and administered as 1 mg/lb (2.2 mg/kg) twice daily. For control of postoperative pain, administer approximately 2 hours before the procedure. Caplets/tablets are scored and dosage should be calculated in half-caplet/tablet increments.

Precautions

See label instructions for complete precautions, warnings and safety information. Federal law restricts this drug to use by or on the order of a licensed veterinarian. RIMADYL should not be used in dogs exhibiting previous hypersensitivity to carprofen. As a class, COX-inhibitory NSAIDs may be associated with gastrointestinal and renal toxicity. When NSAIDs inhibit prostaglandins that cause inflammation, they may also inhibit prostaglandins which maintain normal homeostatic function. The most frequently reported effects have been gastrointestinal signs.

RIMADYL, like other drugs of its class, is not free from adverse reactions. Owners should be advised of the potential for adverse reactions and be informed of the clinical signs associated with drug intolerance. Serious adverse reactions associated with this drug class – including but not limited to gastrointestinal, renal and hepatic signs – can occur without warning and in rare situations result in death. Owners should be advised to discontinue RIMADYL therapy and contact their veterinarian immediately if signs of intolerance are observed.

The use of parenteral fluids during surgery should be considered to reduce the potential risk of renal complications when using NSAIDs perioperatively.

The safe use of RIMADYL in dogs less than 6 weeks of age, pregnant dogs, dogs used for breeding purposes, or in lactating bitches has not been established. Studies to determine the activity of RIMADYL given concomitantly with other protein-bound or similarly metabolized drugs have not been conducted. Drug compatibility should be monitored closely in patients requiring additional therapy. Concurrent use of RIMADYL with other anti-inflammatory drugs, such as corticosteroids and NSAIDs, should be avoided or very closely monitored.

Keep out of reach of children. Not for human use. For use in dogs only.

Q. What should I do if I suspect my dog has arthritis?

A. If your dog exhibits any of the signs of arthritis pain, it’s important to schedule an exam with your veterinarian. He or she can diagnose and recommend the appropriate treatment program for your dog's arthritis. Often, this program may include dietary changes, exercise and a non-steroidal anti-inflammatory drug (NSAID) like Rimadyl to alleviate your dog’s pain. Together, these elements can help relieve joint stress and build muscle strength to make sure your dog remains an active part of your family.

Q. What is Rimadyl®?

A. Rimadyl® (carprofen) is a non-steroidal anti-inflammatory drug (NSAID) developed and approved specifically for use in dogs. Indicated for the relief of pain and inflammation, Rimadyl has been shown to be clinically effective for the relief of signs associated with arthritis.

Q. How do I give Rimadyl to my dog?

A. Rimadyl is available as a scored caplet or chewable tablet. Both are administered orally in 25, 75, and 100 mg doses. Rimadyl also comes in an injectable formula that your veterinarian can administer in the hospital or clinic.

Q. How much Rimadyl do I give my dog?

A. Recommended dosage is 2 mg/lb. of body weight once a day. The veterinarian will recommend the correct dose for your dog.

Q. What does Rimadyl do for a dog with arthritis?

A. Rimadyl relieves arthritis pain, allowing for increased activity and freedom of movement, thereby improving a dog's quality of life. And, the increased activity helps maintain healthy weight, which helps slow down the progression of the disease.

Q. Are there any side effects associated with Rimadyl?

A. As with other pain relievers in this class, rare but serious digestive and liver side effects may occur. Signs of Rimadyl intolerance may include appetite loss, vomiting and diarrhea. Serious adverse reactions associated with this drug class can occur without warning and in rare situations result in death. If these signs occur, discontinue Rimadyl therapy and contact your veterinarian. For additional product details, including drug interaction information, click on Dog Owner Information. Of course, regular monitoring is required for pets on any medications. Rimadyl has been safely used in over 6 million dogs in the US and 10 million dogs worldwide.

Q. Does weight have an effect on arthritis?

A. Excess weight can put undue stress on the joints, ligaments and cartilage. So an obese dog with arthritis is likely to experience more pain than a dog that's trim. If your dog is overweight, ask your veterinarian about diets to help your dog lose weight safely.

Q. What about exercise for my dog with arthritis?

A. When arthritis makes it painful for your dog to move, chances are he’ll be less active. But inactivity can lead to problems too, such as decreased flexibility, joint stiffness, loss of muscle strength, and weight gain. The key is moderation: providing a healthy level of exercise that doesn’t put too much strain on your pet’s joints. Low-impact exercise, such as leash walking and swimming, can increase muscle strength and help stabilize joints. Start your dog's exercise program slowly to give your dog time to get in shape. Begin with several short walks, interspersed with rest periods. If your dog seems to experience more pain after exercise, decrease the exercise time by half. As muscle strength increases, gradually increase the length of your walks. But before starting any exercise program, discuss it with your veterinarian first, to ensure that it’s the right program for your dog.

Of course, if your dog is overweight, don’t overdo exercise and stress the joints until weight loss occurs. And if your dog has a pre-existing condition that puts him at risk for arthritis, such as a torn cruciate ligament, talk to your veterinarian about correcting the condition before starting an exercise program. Exercising a dog with an unstable joint from a torn cruciate ligament will only speed the development of arthritis.

Q. Do you have any tips about exercising my dog?

A. Try to make exercise a regular part of your dog's routine. Take frequent, short walks throughout the week, rather than one long hike on the weekend. Encourage swimming if your dog enjoys it. Swimming gives your dog a great workout with minimal stress on joints. Avoid exercise that involves jumping and leaping, especially for large dogs. The impact from jogging or leaping for a Frisbee is very hard on your pet’s joints. If your dog tends to overdo it, keep him on a leash. Playful activities with other pets can help your dog get exercise. Cover slippery floors with rugs to make sure your dog has firm footing. Make sure you and your dog drink plenty of water before, during and after activity. Avoid exercising during the hottest parts of the day. Early mornings, late afternoons and evenings are best. Stay off hot sidewalks and pavement. If it’s too hot for your bare feet, it’s probably too hot for your dog's paws. Watch for signs that your dog is working too hard: rapid breathing, bright-red gums and lagging behind may indicate fatigue. If you have any questions about you or your pet’s ability to engage in certain activities, contact your physician or your veterinarian.
Is there anything else I can do to make my dog more comfortable?

Q. Is there anything else I can do to make my dog more comfortable? 

A. Gentle massage can be used to increase blood flow to the arthritic areas before activity, and to decrease stiffness after activity. Ask your veterinarian to show you how to correctly massage around affected joints. Applying heat to the joint can help relieve muscle spasm and pain. Just soak a towel in warm water, and apply to the joint for 10 minutes, two to three times a day. Be careful with heat – if the heat pack is too warm, it can irritate the skin. If you notice swelling in the joint area, it is better to apply a cold pack, or ice wrapped in a towel, for 15-20 minutes, three times a day. Also be careful with cold packs. If they are too cold, or are used for too long, they can irritate the skin. It’s important to talk to your veterinarian if you see signs of joint swelling. Like people, dogs with arthritis can experience more discomfort when in a cold, damp environment. Keeping your dog in a warm, dry environment will help increase his comfort. An orthopedic bed may also help relieve some of your dog's morning stiffness. A bed with soft, thick padding will help cushion bones. A circulating warm-water heating pad under the blanket can provide added warmth. To avoid burning the skin, never place your dog directly on the heating pad.

RIMADYL® CAPLETS (carprofen) Tablets

Description: Canine non-steroidal anti-inflammatory drug (NSAID) in two oral dosage forms.

Selectively inhibits cyclooxygenase (COX)-2, which generates prostaglandins involved in inflammation. (In vitro, clinical relevance has not been shown.)

Once-daily dosage provides anti-inflammatory and analgesic effects for 24 hours.

Approved Uses

RIMADYL® CAPLETS are approved for: Pain and inflammation associated with osteoarthritis in dogs.

Control of postoperative pain associated with soft-tissue and orthopedic surgeries in dogs.

Key Features

First and most widely used veterinary NSAID approved in the U.S. for canine use. Caplets are scored and available in three strengths for convenient dosing. Well tolerated in canine safety studies.

Packaging

RIMADYL Caplets are scored and contain 25 mg, 75 mg or 100 mg of carprofen per caplet or tablet. Each caplet size is packaged in bottles of 14, 30, 60 or 180 caplets, or in blister packs containing 4 caplets.

Dosage and Administration

The recommended dosage for oral administration to dogs is 2 mg/lb (4.4 mg/kg) of body weight daily. Total daily dose may be administered as 2 mg/lb of body weight once daily or divided and administered as 1 mg/lb (2.2 mg/kg) twice daily.

For control of postoperative pain, administer approximately 2 hours before the procedure. Caplets are scored, and dosage should be calculated in half-caplet increments.

Precautions

See label instructions for complete precautions, warnings and safety information. Federal law restricts this drug to use by or on the order of a licensed veterinarian. RIMADYL should not be used in dogs exhibiting previous hypersensitivity to carprofen.

As a class, COX-inhibitory NSAIDs may be associated with gastrointestinal and renal toxicity. When NSAIDs inhibit prostaglandins that cause inflammation, they may also inhibit prostaglandins which maintain normal homeostatic function. The most frequently reported effects have been gastrointestinal signs.

RIMADYL, like other drugs of its class, is not free from adverse reactions. Owners should be advised of the potential for adverse reactions and be informed of the clinical signs associated with drug intolerance.

Serious adverse reactions associated with this drug class – including but not limited to gastrointestinal, renal and hepatic signs – can occur without warning and in rare situations result in death. Owners should be advised to discontinue RIMADYL therapy and contact their veterinarian immediately if signs of intolerance are observed.

The use of parenteral fluids during surgery should be considered to reduce the potential risk of renal complications when using NSAIDs perioperatively.

The safe use of RIMADYL in dogs less than 6 weeks of age, pregnant dogs, dogs used for breeding purposes, or in lactating bitches has not been established.

Studies to determine the activity of RIMADYL given concomitantly with other protein-bound or similarly metabolized drugs have not been conducted. Drug compatibility should be monitored closely in patients requiring additional therapy.

Concurrent use of RIMADYL with other anti-inflammatory drugs, such as corticosteroids and NSAIDs, should be avoided or very closely monitored.

Keep out of reach of children. Not for human use. For use in dogs only.

As with other pain relievers in this class, rare but serious digestive and liver side effects may occur. Signs of Rimadyl intolerance may include appetite loss, vomiting and diarrhea. Serious adverse reactions associated with this drug class can occur without warning and in rare situations result in death.

The most common NSAID-related side effects generally involve the stomach (such as bleeding ulcers), and liver or kidney problems. Look for the following Rimadyl side effects that can indicate your dog may be having a problem or may have another medical problem:

• Decrease or increase in appetite
• Vomiting
• Change in bowel movements (such as diarrhea, or black, tarry or bloody stools)
• Change in behavior (such as decreased or increased activity level, incoordination, seizure or aggression)
• Yellowing of gums, skin, or whites of the eyes (jaundice)
• Change in drinking habits (frequency, amount consumed)
• Change in urination habits (frequency, color, or smell)
• Change in skin (redness, scabs, or scratching)

It is important to stop therapy and contact your veterinarian immediately if you think your dog has a medical problem or side effect from Rimadyl therapy. If you have additional questions about possible Rimadyl side effects, talk to your veterinarian.

Rimadyl has been safely used in over 6 million dogs in the US and 10 million dogs worldwide.